Why is lansoprazole not working?
Andrew Mccoy
Updated on January 04, 2026
Changes to your dose
Sometimes your doctor will increase your dose of lansoprazole if it's not working well enough. Depending on the reason you take lansoprazole, you may take a higher dose to begin with, usually for a month or 2. After this, your doctor may recommend that you take a lower dose.Why isn't my acid reflux medicine working?
One of the most common reasons that patients with GERD do not respond to PPI therapy is that they are not compliant with the medication. Several studies have shown that at the end of 1 month, only approximately 50% of patients are taking their PPIs appropriately.What happens if proton pump inhibitors don't work?
If your patient does not get relief from a PPI, all is not lost. If symptoms persist and PPIs are being taken correctly, use endoscopy and Bravo pH monitoring (if endoscopy is negative). An individualized approach incorporating newer technologies may offer relief.Can lansoprazole make symptoms worse?
Lansoprazole can cause a severe allergic reaction. Symptoms can include: rash. face swelling.Why is my PPI not working?
Many of these patients do not suffer from GERD, but may have underlying functional heartburn or atypical chest pain. Other causes of failure to respond to PPIs include inadequate acid suppression, non-acid reflux, oesophageal hypersensitivity, oesophageal dysmotility and psychological comorbidities.What Happens When GERD Patients Don't Respond to PIPs
Why is my acid reflux getting worse?
Factors that can aggravate acid reflux include: Smoking. Eating large meals or eating late at night. Eating certain foods (triggers) such as fatty or fried foods.Can you take 2 lansoprazole a day?
For severe illness, you can take it twice a day, in the morning and in the evening. You should start to feel better in 2 to 3 days, but it may take up to 4 weeks for lansoprazole to fully control your acid symptoms. Common side effects include headache, diarrhoea and stomach pain.Can you take 60 mg of lansoprazole?
Adults—60 milligrams (mg) once a day before a meal. Your doctor may adjust your dose as needed. Children—Use and dose must be determined by your doctor.What should you not take with lansoprazole?
Common medications that may interact with lansoprazole include:
- aminophylline or theophylline.
- astemizole.
- bisphosphonates, such as alendronate, etidronate, or risedronate.
- clopidogrel.
- digoxin.
- HIV medications (eg, atazanavir, indinavir, ritonavir, or saquinavir)
- methotrexate.