Which antidepressant causes most weight gain?
Mia Horton
Updated on January 16, 2026
Tricyclic antidepressants such as amitriptyline and tetracyclic antidepressants such as mirtazapine are linked to the most weight gain.
Which antidepressants do not cause weight gain?
Some antidepressants may be less likely to affect weight. Effexor and Serzone generally do not cause weight gain, while Wellbutrin can cause weight loss.Which causes more weight gain Prozac or Zoloft?
That being said, one study published in 2016 in the Journal of Clinical Medicine found that Zoloft can lead to an overall greater weight gain than Prozac when taken long-term. The study found that people taking Prozac for two years gained an average of 4.6 pounds.Why do most antidepressants cause weight gain?
Antidepressants interfere with serotonin, the neurotransmitter that regulates anxiety and mood while also controlling appetite. In particular, these changes may increase cravings for carbohydrate-rich foods, such as bread, pasta, and desserts.What are the best antidepressants for weight loss?
Most antidepressant medications are more commonly associated with weight gain, but there are three that have been connected to weight loss:
- Bupropion (Wellbutrin)
- Fluoxetine (Prozac)
- Duloxetine (Cymbalta)