What is the difference between bupropion XL and SR?
Jessica Wood
Updated on January 13, 2026
Wellbutrin XL and Wellbutrin SR both have the same active ingredient, but Wellbutrin XL is released in your body slower than Wellbutrin SR. Wellbutrin XL is FDA-approved to treat depression and prevent seasonal affective disorder (SAD). Wellbutrin SR is approved to treat depression and help people quit smoking.
Is Bupropion SR and XL the same?
Official answer. Wellbutrin XL and SR are different formulations of the same drug. One is not better than the other. The differences between Wellbutrin XL and Wellbutrin SR are found in the dosing and the approved uses.Does Wellbutrin XL or SR cause weight loss?
Both Wellbutrin XL and Wellbutrin SR may cause weight gain or weight loss, but weight loss is more common. Not everyone taking these drugs will experience a change in weight. Weight changes are considered a side effect for both Wellbutrin XL and Wellbutrin SR.What does bupropion SR do?
Bupropion is an antidepressant used for smoking cessation and to treat a variety of conditions, including depression and other mental/mood disorders. Antidepressants can help prevent suicidal thoughts/attempts and provide other important benefits.How does bupropion SR make you feel?
Commonly Observed Adverse ReactionsWELLBUTRIN SR 400 mg per day: Abdominal pain, agitation, anxiety, dizziness, dry mouth, insomnia, myalgia, nausea, palpitation, pharyngitis, sweating, tinnitus, and urinary frequency.