What's better Prozac or Wellbutrin?
Andrew Mclaughlin
Updated on January 15, 2026
Is Wellbutrin or Prozac better? Wellbutrin and Prozac are similarly effective for treating depression. The best antidepressant is the one that causes the least side effects and is more cost effective, depending on the situation. Wellbutrin causes less sexual side effects and weight gain than SSRIs like Prozac.
Is Prozac better than Wellbutrin for anxiety?
Wellbutrin (Bupropion) Improves mood and helps you relax. Prozac (fluoxetine) is good for treating depression and anxiety. It's more energizing than other antidepressants, so it may not be the best choice for people who have trouble sleeping.Should you take Prozac and Wellbutrin together?
Should you take Prozac and Wellbutrin together? Due to interactions between the two drugs, you shouldn't take Wellbutrin and Prozac together. This can lead to an increased risk of serotonin syndrome and seizures.Whats the difference between bupropion and Prozac?
Wellbutrin (bupropion) and Prozac (fluoxetine) are antidepressants used to manage major depression. Wellbutrin is also used to treat seasonal affective disorder. Prozac is also used to treat bulimia, obsessive-compulsive disorder (OCD), panic disorder, and premenstrual dysphoric disorder (PMDD).Is Wellbutrin the best antidepressant?
Wellbutrin has been found to be at least as effective as other popularly prescribed antidepressant medication. There is also less chance of weight gain, sleepiness, and sexual dysfunction than with other forms of treatment. It may even work actively against sexual dysfunction resulting from previous antidepressant use.Do Antidepressants Work? Wellbutrin vs Prozac
Why do doctors not prescribe Wellbutrin?
Because of its activating/stimulating property, bupropion is rarely prescribed by physicians when a patient has comorbid anxiety disorder or symptoms of central nervous system activation (Zimmerman et al., 2005) .What is the highest rated antidepressant?
1. SSRIs
- Citalopram (Celexa)
- Escitalopram (Lexapro)
- Fluoxetine (Prozac)
- Paroxetine (Paxil)
- Sertraline (Zoloft)